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01.04.2011
Website of the project DNAGen by Team Concordia at Concordia University, Montreal, Canada has officially been launched!
08.04.2011
Initial proposal for the project "DNAGen" has been submitted for review. The team is hopeful that it'll be accepted for further research by the faculty members at Concordia University.
Welcome to our website!

Abstract

Random numbers have a vital importance in various fields of science and arts and their applications range from Telecommunications to Gambling and Data Sampling. Various methods exist in literature for the generation of random numbers, they can be Pseudorandom ...More

Objectives

The project's objectives can be outlined as follows:
1. To understand the concepts behind implementing physical and mathematical systems based on biological designs.
2. To illustrate the applicability of biological systems for real-life scenarios.
... More

Background

Even though it may look simple at first sight to give a definition of what a random number is, it proves to be quite difficult in practice. A random number is generated by a process whose outcome is unpredictable, and which cannot be ...More

Methods

To design our system we use a fragment of Dna derived from the lambda phage genome it contains genes encoding C1 represssor, cII and CIII assistand proteins, N antiterminator protein, and a mutated version of Cro repressor. It is flanked byh specific sequences that allow the fragment to be intregrated into bacterial chromoseome via in vivo recombination. Additionally, it has a taetraclin resistance selection marker. To introduce inducibility into the system the LacI binding site is to be inserted right downstream of -10 box of Pr promoter. Therefore, no transcription of Cro will take place until Isopropyl ß-D-1-thiogalactopyronoside (IPTG) is added to the medium. The other network components include Enhanced Green Fluorescent Protein (EGFP) encoding gene followed by recombinase Cre gene fused ..More

The Team

This project is part of the coursework for COEN691A Synthetic Biology course at Concordia University, Montreal. The instructors are Dr. Nawwaf Kharma an Electrical Engineering Department professor, and Dr. Luc Varin a professor at Biology department of Concordia University. The student members are Qaiser Habib and Raheel Tariq, graduate students of Electrical Engineering and Savasteeva Natasha, an undergraduate student of the Biology department. Qaiser is expert at programming, web designing and has IEEE conference publications in the fields of Genetic Programming and Wireless Networks, Raheel's area of expertise is digital design, mathematical models and technical documentation, while Savasteeva is an expert at Biological systems, molecular biology and Gene Regulatory Networks. Member details, profiles and skills/roles will soon be uploaded...More

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