Pilot analysis of the immune response to fungal antigens in subjects working in humidity damaged houses
Tiilikainen, A. S., Heikkinen, I., Venp??, K., Karttunen, R.
2001
In "Bioaerosols, Fungi and Mycotoxins: Health Effects, Assessment, Prevention and Control", Edited by Johanning, E., Boyd Printing, Albany, New York
Anti-mold IgG antibodies, lymphocyte stimulation by mold antigens, anti-mold immunity, anti-mold immunity and health impairment, mold-induced cytokine excretion in vitro
Tiilikainen, A. S., Heikkinen, I., Venp??, K., Karttunen, R., (2001), "Pilot analysis of the immune response to fungal antigens in subjects working in humidity damaged houses", In "Bioaerosols, Fungi and Mycotoxins: Health Effects, Assessment, Prevention and Control", Edited by Johanning, E., Boyd Printing, Albany, New York.
| Abstract.
Although the proportion of anti-mold IgG antibody producers was largely the same among different groups of subjects tested, the highest OD-readings in EIA technique were seldom seen in symptomless controls, but generally in association with any allergy of the "mold exposed" subjects or in patients referred to specialist analysis at the Oulu University Hospital outpatient clinic for oto-rhino-laryngology. Some subjects in each group were distinctly multi-immune ("responders" = R) and some just occasionally reactive ("low responders" = LR) against a panel of 12-16 mold antigens; of the 34 allergic subjects 6 were R and 3 LR. In vitro cultures of patient lymphocytes usually responded with a lower cytokine production to Aspergillus fumigatus antigen than to other mold antigens, in contrast to responses of lymphocytes from healthy controls. More often than not, R lymphocytes showed higher cytokine production than did LR lymphocytes; more frequently in healthy controls than in patients. |
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Related Concepts
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Related Resources:
 Bioaerosols, Fungi and Mycotoxins, Ed. by Johanning, E.
"papers presented at the September, 1998 Third International Conference in Saratoga Springs, New York. clinical and epidemiological studies and technical reports on an emerging public health topic affecting people in indoor environments at work and at home."
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