WELCOME TO THE LABORATORY OF CARDIOVASCULAR FLUID DYNAMICS
Disclaimer: By downloading the .pdf files below, you recognize that it is for your personal use only.
Note: For your convenience, publication are grouped in different categories.
Heart valve disease/Mitral Valve
Wiener PC, Darwish A, Friend E, Kadem L, Pressman GS (2021) Energy loss associated with in-vitro modeling of mitral annular calcification. PLOS ONE 16(2): e0246701.
Wiener PC, Friend EJ, Bhargav R, Radhakrishnan K, Kadem L, Pressman GS. Color Doppler splay: a clue to the presence of significant mitral regurgitation. Journal of the American Society of Echocardiography. 2020 Oct 1;33(10):1212-9. This article has been commented in an editorial written by PB Bertrand et al.
Sargordi M, Chtchetinina A, Di Labbio G, Ng HD, Kadem L. Pulsatile twin parallel jets through a flexible orifice with application to edge-to-edge mitral valve repair. Physics of Fluids. 2020 Dec 1;32(12):121702
Papolla C, Darwish A, Kadem L, Rieu R. Impact of Mitral Regurgitation on the Flow in a Model of a Left Ventricle. Cardiovascular Engineering and Technology. 2020 Sep 30:1-1.
Gaillard E, Kadem L, Durand LG. A Simple Non-Invasive Method to Predict Mitral Valve Geometric Orifice Area Following an Edge to Edge Repair. Journal of Heart Valve Disease 2011; 1: 1-5
Tanné D, Bertrand E, Kadem L, Pibarot P, Rieu R. Assessment of left heart and pulmonary circulation flow dynamics by a new pulsed mock circulatory system. Experiments in Fluids 2010; 5: 837-850. [pdf]
Tanné D, Kadem L, Rieu R, Pibarot P. Hemodynamic Impact of Mitral Prosthesis-Patient Mismatch: An in Silico Study. Journal of Applied Physiology 2008; 105(6):1916-26. [pdf]
Prosthetic heart valves/Mechanical Heart Valves
Mirvakili N, Di Labbio G, Saleh W, Kadem L. Flow characteristics in a model of a left ventricle in the presence of a dysfunctional mitral mechanical heart valve. Journal of Visualization. 2020 Feb;23(1):1-8.
Darwish A, Di Labbio G, Saleh W, Smadi O, Kadem L. Experimental investigation of the flow downstream of a dysfunctional bileaflet mechanical aortic valve. Artificial Organs. 2019 Oct;43(10):E249-63. (arXiv)
Evin M, Guivier-Curien C, Pibarot P, Kadem L, Rieu R. Are the Current Doppler Echocardiography Criteria Able to Discriminate Mitral Bi-leaflet Mechanical Heart Valve Malfunction? an In Vitro Study. Accepted in Artificial Organs (2015)
Smadi O, Garcia J, Pibarot P, Gaillard E, Hassan I, Kadem L. Accuracy of Doppler-Echocardiographic Parameters for the Detection of Aortic Bileaflet Mechanical Prosthetic Valve Dysfunction. Accepted in European Heart Journal – Cardiovascular Imaging (2013) [link] /in case you do not have access, please email me/
Evin M, Pibarot P, Guivier-Curien C, Tanné D, Kadem L, Rieu R. Localized Transvalvular Pressure Gradients in Mitral Bileaflet Mechanical Heart Valves and Impact on Gradient Overestimation by Doppler. Journal of American Society of Echocardiography 2013; 26(7): 791-800. [link] /in case you do not have access, please email me/
Smadi O, Hassan IG, Pibarot P, Kadem L. Numerical and experimental investigations of pulsatile blood flow pattern through a dysfunctional mechanical heart valve. Journal of Biomechanics 2010; 43(8): 1565-1572. [pdf]
Smadi O, Fenech M, Hassan IG, Kadem L. Flow Through a Defective Mechanical Heart Valve: a Steady Flow Analysis. Medical Engineering Physics 2009; 31(3): 295-305. [pdf]
Mouret F, Kadem L, Bertrand E, Dumesnil JG, Pibarot P, Rieu R. Mitral Prosthesis Opening and Flow Dynamics in a Model of Left Ventricle: an in vitro Study on a Monoleaflet Mechanical Valve. Cardiovascular Engineering 2005; 5(1):13-20. [pdf]
Fluid Dynamics/Lagrangian Analysis
Darwish A, Di Labbio G, Saleh W, Kadem L. In vitro characterization of Lagrangian fluid transport downstream of a dysfunctional bileaflet mechanical aortic valve. American Institute of Physics Advances. 2020 Sep 1;10(9):095319. (Open Access)
Di Labbio G, Vétel J, Kadem L. Material transport in the left ventricle with aortic valve regurgitation. Physical Review Fluids. 2018 Nov 16;3(11):113101. (arXiv)
Heart valve disease/pulmonary valve
Mikhail A, Di Labbio G, Darwish A, Kadem L. How pulmonary valve regurgitation after tetralogy of fallot repair changes the flow dynamics in the right ventricle: An in vitro study. Medical Engineering & Physics. 2020 Sep 1;83:48-55.
Heart valve disease/Aortic Regurgitation
Di Labbio G, Ben Assa E, Kadem L. Experimental Investigation of the Effect of Heart Rate on Flow in the Left Ventricle in Health and Disease—Aortic Valve Regurgitation. Journal of Biomechanical Engineering. 2020 May 1;142(5).
Di Labbio G, Kadem L. Response to letter to the editor:’Left ventricular flow in the presence of aortic regurgitation’. Journal of biomechanics. 2019 Apr;87:212-4.
Di Labbio G, Kadem L. Jet collisions and vortex reversal in the human left ventricle. Journal of biomechanics. 2018 Sep 10;78:155-60. (arXiv)
Heart valve disease/Transcatheter valves
Stanová V, Zenses AS, Thollon L, Kadem L, Barragan P, Rieu R, Pibarot P. Effects of hemodynamic conditions and valve sizing on leaflet bending stress in self‐expanding transcatheter aortic valve: An in vitro study. Artificial Organs. 2020 Jan 29.
Maleki H, Shahriari S, Labrosse M, Rodés-Cabau J, Pibarot P, Kadem L. Effect of Aortic Annulus Size and Prosthesis Oversizing on the Hemodynamics and Leaflet Bending Stress of Transcatheter Valves: An In Vitro Study. Accepted in Canadian Journal of Cardiology (2015)
Maleki H, Shahriari S, Labrosse M, Pibarot P, Kadem L. An in Vitro Model of Aortic Stenosis for the Assessment of Transcatheter Aortic Valve Implantation. Accepted in Journal of Biomechanical Engineering (Tech. Note) (2014)
Fluid Dynamics/Modal Decomposition
Heat Transfer
Younes A, Hassan I, Kadem L. A Semi-Analytical Model of Heat Transfer and Pressure Drop in Annular Flow Regime for Flow Boiling in a Horizontal Micro-Tube at Uniform Heat Flux. Transactions of the Canadian Society for Mechanical Engineering. 2019 Sep 16(ja).
Younes A, Hassan I, Kadem L. Investigation of Bubble Frequency for Slug Flow Regime in a Uniformly Heated Horizontal Microchannel. Journal of Heat Transfer (2017)
ElNady T, Hassan I, Kadem L. Experimental Investigation of Louver Cooling Scheme on Gas Turbine Stator. Heat Transfer Engineering (2016)
Elnady T, Hassan I, Kadem L. Cooling Effectiveness of Shaped Film Holes for Leading Edge. Experimental Thermal and Fluid Science 2013; 44: 649-661 [link]
Blunt Traumatic Aortic Rupture
Di Labbio G, Keshavarz-Motamed, Z, Kadem L Numerical simulation of flows in a circular pipe transversely subjected to a localized impulsive body force with applications to blunt traumatic aortic rupture”. Fluid Dynamics Research (2017) (arXiv)
Maraouch G, Horton CH, Fanaberia J, Malorni E, Mignacca GC, Cohen M, Kadem L. Experimental Investigation of Aortic Pressure Variations Following a Simulated Thoracic Impact. arXiv preprint arXiv:2105.05846. 2021 May 12.
Coarctation of the aorta
Keshavarz-Motamed Z, Edelman ER, Motamed PK, Garcia J, Dahdah N, Kadem L. The role of aortic compliance in determination of coarctation severity: lumped parameter modeling, in vitro study and clinical evaluation. Accepted in Journal of Biomechanics (2015)
Keshavarz-Motamed Z, Garcia J, Gaillard E, Maftoon N, G, DiLabbio, Cloutier G, Kadem L. Effect of Coarctation of the Aorta and Bicuspid Aortic Valve on Flow Dynamics and Turbulence in the Aorta using Particle Image Velocimetry. Accepted in Experiments in Fluids (2014)
Keshavarz-Motamed Z, Garcia J, Kadem L. Fluid Dynamics of Coarctation of the Aorta and Effect of Bicuspid Aortic Valve. PlosOne 2013; 8(8): e72394 [link] /Open Access/
Keshavarz-Motamed Z, Garcia J, Maftoon N, Bedard E, Chetaille P, Kadem L. A New Approach for the Evaluation of the Severity of Coarctation of the Aorta Using Doppler Velocity Index: In vitro Validation and Clinical Implications. Accepted in Journal of Biomechanics (2012) [pdf]
Z. Keshavarz-Motamed, J. Garcia, P. Pibarot, E. Larose, L. Kadem. Modeling the impact of concomitant aortic stenosis and coarctation of the aorta on left ventricular workload. Journal of Biomechanics 2011; 44: 2817-2825 [pdf]
Keshavarz-Motamed Z and Kadem L. 3D Pulsatile Flow in a Curved Tube with Coexisting Model of Aortic Stenosis and Coarctation of the Aorta. Medical Engineering and Physics 2010; 33(3): 315-324 [pdf]
Pediatric cardiology
Heart Valve disease/Aortic valve stenosis
Benevento E, Djebbari A, Keshavarz-Motamed Z, Cecere R, Kadem L. Hemodynamic changes following aortic valve bypass: a mathematical approach. PloS one. 2015 Apr 16;10(4):e0123000.
Keshavarz-Motamed Z, Garcia J, Gaillard E, Capoulade R, LeVen F, Cloutier G, Kadem L, Pibarot P. Non-invasive Determination of Left Ventricular Workload in Patients with Aortic Stenosis using Magnetic Resonance Imaging and Doppler Echocardiography. Accepted in PlosOne (2013)
Maleki H, Shahrokh S, Durand LG, Labrosse M, Kadem L. A Metric for the Stiffness of Calcified Aortic Valves using a Combined Computational and Experimental Approach. Accepted in Medical and Biological Engineering and Computing (2013) [link] /in case you do not have access, please email me/
Maleki H, Shahrokh S, Durand LG, Labrosse M, Kadem L. A Metric for the Stiffness of Calcified Aortic Valves using a Combined Computational and Experimental Approach. Accepted in Medical and Biological Engineering and Computing (2013) [link] /in case you do not have access, please email me/
Garcia J, Pibarot P, Capoulade R, Le Ven F, Kadem L, Larose E. Usefulness of Cardiovascular Magnetic Resonance Imaging for the Evaluation of Valve Opening and Closing Kinetics in Aortic Stenosis. Accepted in European Heart Journal – Cardiovascular Imaging (2012) [link] /in case you do not have access, please email me/
Garcia J, Marrufo OR, Rodriguez AO, Larose E, Pibarot P, Kadem L. Cardiovascular Magnetic Resonance Evaluation of Aortic Stenosis Severity using Single Plane Measurement of Effective Orifice Area. Journal of Cardiovascular Magnetic Resonance 2012; 14: 23 [link] /Open Access/
Gaillard E, Kadem L, Pibarot P, Durand LG. Effect of a concomitant asymmetric septal hypertrophy on the assessment of the severity of an aortic valve stenosis: an in-vitro study. Accepted in Journal of Heart Valve Disease (2011)
Gaillard E, Kadem L, Pibarot P, Durand LG. Optimization of Doppler echocardiographic velocity measurements using an automatic contour detection method. Ultrasound in Medicine and Biology 2010; 36(9): 1513-1524. [pdf]
Gaillard E, Kadem L, Pibarot P, Durand LG. In vitro Investigation of the Impact of aortic valve stenosis severity on left coronary artery flow. Journal of Biomechanical Engineering 2010; 132: 044502 – 1:4.
Garcia D, Pibarot P, Kadem L, Durand LG. Respective Impacts of Aortic Stenosis and Systemic Hypertension on the Left Ventricular Hypertrophy. Journal of Biomechanics 2007; 40 (5): 972-980. [pdf]
Kadem L, Garcia D. Are we using the right fluid mechanics principles? Ann Thorac Surg. 2007; 83(1):354 [letter to editor]
Garcia D, Kadem L, Savéry D, Pibarot P, Durand LG. Analytical modeling of instantaneous maximal transvalvular pressure gradient in aortic stenosis. J Biomech. 2006; 39(16): 3036-3044. [pdf]
Garcia D, Kadem L. What do you mean by aortic valve area: geometric orifice area, effective orifice area or Gorlin area? J Heart Valve Dis. 2006; 15 :601-608. [pdf]
Kadem L, Garcia D, Durand LG, Rieu R, Dumesnil JG, Pibarot P. Value and limitations of peak-to-peak gradient for evaluation of aortic stenosis. J Heart Valve Dis. 2006; 15: 609-616.[pdf]
Blais C, Burwash IG, Mundigler G, Dumesnil JG, Loho N, Rader F, Baumgartner H, Beanlands RS, Chayer B, Kadem L, Garcia D, Durand LG, Pibarot P. The Projected Valve Area at Normal Flow Rate Improves the Assessment of Stenosis Severity in Patients with Low Flow, Low Gradient Aortic Stenosis. The Multicenter TOPAS (Truly Or Pseudo Severe Aortic Stenosis) Study. Circulation 2006; 113:711-721. This article has been commented in an editorial written by A. Grayburn. [pdf] [editorial]
Kadem L, Rieu R, Dumesnil JG, Durand LG, Pibarot P. Flow Dependent Changes in Doppler Derived Aortic Valve Effective Orifice Area are Real and not Due to Artifact. Journal of American College of Cardiology 2006; 47(1): 131-137. This article has been commented in an editorial written by H. Baumgartner. [pdf]
Kadem L, Knapp Y, Pibarot P, Durand LG, Rieu R. A New Experimental Technique for the Determination of Effective Orifice Area based on the Acoustical Source Term. Experiments in Fluids 2005; 39: 1051-1060. [pdf]
Briand M, Dumesnil JG, Kadem L, Tongue A, Rieu R, Garcia D, Pibarot P. Reduced Systemic Arterial Compliance Impacts Significantly on LV Afterload and Function in Aortic Stenosis: Implications for Diagnosis and Treatment.Journal of American College of Cardiology 2005; 46(2): 291-298. This article has been commented in an editorial written by KL. Peterson. [pdf] [editorial]
Kadem L, Dumesnil JG, Rieu R, Durand LG, Garcia D, Pibarot P. Impact of systemic hypertension on the assessment of aortic stenosis. Heart. 2005; 91(3):354-61. This article has been commented in an editorial written by J. Bermejo. [pdf] [editorial]
Garcia D, Dumesnil JG, Durand LG, Kadem L, Pibarot P. Discrepancies between catheter and Doppler estimates of valve effective orifice area can be predicted from the pressure recovery phenomenon. Practical implications with regards to quantification of aortic stenosis severity. Journal of American College of Cardiology 2002; 41(3):435-442.This article has been commented in an editorial written by RA. Levine. [pdf] [editorial]
Kadem L, Pibarot P, Dumesnil JG, Mouret F, Garitey V, Durand LG, Rieu R. Independent Contribution of Left Ventricular Ejection Time to the Mean Gradient in Aortic Stenosis. Journal of Heart Valve Disease 2002; 11(5):615-23. [pdf]
Smoothed Particle Hydrodynamics
Shahriari S, Hassan I, Kadem L. Modelling Unsteady Flow Characteristics using Smoothed Particle Hydrodynamics. Applied Mathematical Modelling 2013; 37(3): 1431-1450 [pdf]
Shahriari S, H. Maleki, Hassan I, Kadem L. Evaluation of Shear Stress Accumulation on Blood Components in Normal and Dysfunctional Bileaflet Mechanical Heart Valves using Smoothed Particle Hydrodynamics. Journal of Biomechanics 2012; 45(15): 2637-2644 [link] /in case you do not have access, please email me/
Shahriari S, Kadem L, Rogers BD, Hassan IG. Smoothed Particle Hydrodynamics Method Applied to Pulsatile Flow inside a Rigid Two-Dimensional Model of Left Heart Cavity. Accepted in International Journal of Numerical Methods in Biomedical Engineering (2012) [pdf]
Fluid dynamics/General fluid dynamics
Mandour A, Fayed M, Ait Abderrahmane H, Ng HD, Kadem L, Vatistas GH. Symmetry-Breaking of Interfacial Polygonal Patterns and Synchronization of Travelling Waves within a Hollow-Core Vortex. Chaotic Modeling and Simulation 2012; 1: 257-271.
Saleh W, Bowden RC, Hassan IG, Kadem L. Techniques of PIV in Stratified Two-Phase Headers. Experimental Thermal and Fluid Science 2011; 35(1): 82-95 [link]
Saleh W, Bowden RC, Hassan IG, Kadem L. Theoretical Analysis of the Onset of Gas Entrainment from a Stratified Region through Multiple Branches. International Journal of Multiphase Flow 2011; 37(10): 1348-1357
Rafiqul Haque M, Fayed M, Gunter A; Smadi O, Kadem L, Ng HD. Numerical Simulation and Flow Visualization Using Soap Film of the Self-Organized Vortex Structure in the Wake of an Array of Cylinders
Journal of Visualization 2011; 14(4): 311-314
Gunter A, Smadi O, Kadem L, Ng HD. Visualization of an imploding circular wave front and the formation of a central vertical jet. Journal of Visualization 2011; 14(1): 19-22
Saleh W, Bowden RC, Hassan IG, Kadem L. Two-Phase Flow Structure in Dual Discharging – Stereo PIV Measurements. Experimental Thermal and Fluid Science 2010; 34: 1016–1028
Keshavarz-Motamed Z, Kadem L, Dolatabadi A. Effects of Dynamic Contact Angle on Numerical Modeling of Electrowetting in Parallel Plate Microchannels. Microfluidic and Nanofluidic 2010; 8: 47-56. [pdf]
Saleh W, Bowden RC, Hassan IG, Kadem L.
A Hybrid model to Predict the Onset of Gas Entrainment with Surface Tension Effect. Journal of Fluid Engineering 2009; 131: 011305-1-10.
Book chapters
Labrosse MR and Kadem L. Experimental Methods in Cardiovascular Mechanics. In Cardiovascular Mechanics edited by Labrosse MR. CRC Press 2019.
Kadem L. Aortic Stenosis and Systemic Hypertension: See Beyondb the Valve. Heart Valves: Disorders, Repair, and Replacement, Nova Science Publishers, 2009.