WELCOME TO THE LABORATORY OF CARDIOVASCULAR FLUID DYNAMICS

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Note: For your convenience, publication are grouped in different categories.

Heart Valve disease/Aortic valve stenosis

Benevento E, Djebbari A, Keshavarz-Motamed Z, Cecere R, Kadem L. Hemodynamic changes following aortic valve bypass: a mathematical approach. PloS one. 2015 Apr 16;10(4):e0123000.

Keshavarz-Motamed Z, Garcia J, Gaillard E, Capoulade R, LeVen F, Cloutier G, Kadem L, Pibarot P. Non-invasive Determination of Left Ventricular Workload in Patients with  Aortic Stenosis using  Magnetic Resonance Imaging and Doppler Echocardiography. Accepted in PlosOne (2013)

Maleki H, Shahrokh S, Durand LG, Labrosse M, Kadem L. A Metric for the Stiffness of Calcified Aortic Valves using a Combined Computational and Experimental Approach. Accepted in Medical and Biological Engineering and Computing (2013) [link] /in case you do not have access, please email me/

Maleki H, Shahrokh S, Durand LG, Labrosse M, Kadem L. A Metric for the Stiffness of Calcified Aortic Valves using a Combined Computational and Experimental Approach. Accepted in Medical and Biological Engineering and Computing (2013) [link] /in case you do not have access, please email me/

Garcia J, Pibarot P, Capoulade R, Le Ven F, Kadem L, Larose E. Usefulness of Cardiovascular Magnetic Resonance Imaging for the Evaluation of Valve Opening and Closing Kinetics in Aortic Stenosis. Accepted in European Heart Journal – Cardiovascular Imaging (2012) [link] /in case you do not have access, please email me/

Garcia J, Marrufo OR, Rodriguez AO, Larose E, Pibarot P, Kadem L. Cardiovascular Magnetic Resonance Evaluation of Aortic Stenosis Severity using Single Plane Measurement of Effective Orifice Area. Journal of Cardiovascular Magnetic Resonance 2012; 14: 23 [link] /Open Access/

Gaillard E, Kadem L, Pibarot P, Durand LG. Effect of a concomitant asymmetric septal hypertrophy on the assessment of the severity of an aortic valve stenosis: an in-vitro study. Accepted in Journal of Heart Valve Disease (2011)

Gaillard E, Kadem L, Pibarot P, Durand LG. Optimization of Doppler echocardiographic velocity measurements using an automatic contour detection method. Ultrasound in Medicine and Biology 2010; 36(9): 1513-1524. [pdf]

Gaillard E, Kadem L, Pibarot P, Durand LG. In vitro Investigation of the Impact of aortic valve stenosis severity on left coronary artery flow. Journal of Biomechanical Engineering 2010; 132: 044502 – 1:4.

Garcia D, Pibarot P, Kadem L, Durand LG. Respective Impacts of Aortic Stenosis and Systemic Hypertension on the Left Ventricular Hypertrophy. Journal of Biomechanics 2007; 40 (5): 972-980. [pdf]

Kadem L, Garcia D. Are we using the right fluid mechanics principles? Ann Thorac Surg. 2007; 83(1):354 [letter to editor]

Garcia D, Kadem L, Savéry D, Pibarot P, Durand LG. Analytical modeling of instantaneous maximal transvalvular pressure gradient in aortic stenosis. J Biomech. 2006; 39(16): 3036-3044. [pdf]

Garcia D, Kadem L. What do you mean by aortic valve area: geometric orifice area, effective orifice area or Gorlin area? J Heart Valve Dis2006; 15 :601-608. [pdf]

Kadem L, Garcia D, Durand LG, Rieu R, Dumesnil JG, Pibarot P. Value and limitations of peak-to-peak gradient for evaluation of aortic stenosis. J Heart Valve Dis. 2006; 15: 609-616.[pdf]

Blais C, Burwash IG, Mundigler G, Dumesnil JG, Loho N, Rader F, Baumgartner H, Beanlands RS, Chayer B, Kadem L, Garcia D, Durand LG, Pibarot P. The Projected Valve Area at Normal Flow Rate Improves the Assessment of Stenosis Severity in Patients with Low Flow, Low Gradient Aortic Stenosis. The Multicenter TOPAS (Truly Or Pseudo Severe Aortic Stenosis) Study. Circulation 2006; 113:711-721. This article has been commented in an editorial written by A. Grayburn. [pdf] [editorial]

Kadem L, Rieu R, Dumesnil JG, Durand LG, Pibarot P. Flow Dependent Changes in Doppler Derived Aortic Valve Effective Orifice Area are Real and not Due to Artifact. Journal of American College of Cardiology 2006; 47(1): 131-137. This article has been commented in an editorial written by H. Baumgartner. [pdf]

Kadem L, Knapp Y, Pibarot P, Durand LG, Rieu R. A New Experimental Technique for the Determination of Effective Orifice Area based on the Acoustical Source Term. Experiments in Fluids 2005; 39: 1051-1060. [pdf]

Briand M, Dumesnil JG, Kadem L, Tongue A, Rieu R, Garcia D, Pibarot P. Reduced Systemic Arterial Compliance Impacts Significantly on LV Afterload and Function in Aortic Stenosis: Implications for Diagnosis and Treatment.Journal of American College of Cardiology 2005; 46(2): 291-298. This article has been commented in an editorial written by KL. Peterson. [pdf] [editorial]

Kadem L, Dumesnil JG, Rieu R, Durand LG, Garcia D, Pibarot P. Impact of systemic hypertension on the assessment of aortic stenosis. Heart. 2005; 91(3):354-61. This article has been commented in an editorial written by J. Bermejo. [pdf] [editorial]

Garcia D, Dumesnil JG, Durand LG, Kadem L, Pibarot P. Discrepancies between catheter and Doppler estimates of valve effective orifice area can be predicted from the pressure recovery phenomenon. Practical implications with regards to quantification of aortic stenosis severity. Journal of American College of Cardiology 2002; 41(3):435-442.This article has been commented in an editorial written by RA. Levine. [pdf] [editorial]

Kadem L, Pibarot P, Dumesnil JG, Mouret F, Garitey V, Durand LG, Rieu R. Independent Contribution of Left Ventricular Ejection Time to the Mean Gradient in Aortic Stenosis. Journal of Heart Valve Disease 2002; 11(5):615-23. [pdf]